cure the disease of HIV / AIDS

The world is always concerned about a virus called HIV / AIDS. Imagine, this virus can infect humans without detectable and can only be felt if it had stepped on an advanced stage of severe and lead to death.
While the spread of HIV / AIDS virus is so deadly is very spread to various parts of the country, cities and even villages, so far not yet found a drug that can actually cure the disease that attacks the human immune system.
Drugs that exist today are simply slow down the spread in the body of the patient, but did not heal completely. In addition to these weaknesses, the price is relatively expensive, difficult to be found, and have a high failure rate in the process of holding the spread of the virus. Especially after it emerged that these drugs have side effects for the Drinker.



The researchers and scientists from the University of California Los Angeles (UCLA) and Purdue University in Indiana, United States (U.S.), have discovered new clues about the side effects of anti-AIDS (Acquired Immune Deficiency Syndrome) which is widely used, that is causing hoarding fat.
Scientific report issued by the journal Proceedings of the National Academy of Science (07/16/2007), reported, protease inhibitors, an important component in the mixture of HIV drugs, it can help to precipitate the fat that often makes the patient weak. In addition, protease inhibitors also cause premature aging.
American scientists investigated the effects of protease inhibitors on mice and human cells. The results indicate the substance is precipitated and form protein clumps called prolamin A. This is because movement of other proteins that are named ZMPSTE24 not be able to change the prolamin A bermanfat substance for the body.
Christine Hrycyna from Purdue University, one of the scientists who participated in the study, said that protease inhibitors can cause metabolic disorders such as accumulation of fat in the blood, high blood pressure, and increased risk of diabetes.These substances also trigger a condition called lipodystrophy or fat distribution on the body, such as back, neck, and cheeks. Such cases are often referred to as buffalo hump.
The conclusion the scientists also based on the condition of tens of thousands of patients with HIV (Human Immunodeficiency Virus) which mengonumsi anti-HIV drugs that contain protease inhibitors in seluuh world. In fact, the patients were experiencing premature aging from the effects of these substances or often referred to as Hutchinson-Gilford progeria. Patients to be looked older than actual age. "These side effects may not only be caused by one simple condition," said Hrycyna.
The researchers also tested some other drugs commonly used in a mixture of AIDS drugs, known as highly active antiretroviral therapy (ARV) is very active, or known by the name of HAART. Only the drug that does not cause protein accumulation. For that, researchers will try to examine several types of drugs commonly given to people with AIDS, to compare with their findings.
Anti HIV / AIDS called antiretrovirals (ARVs) are now the subject of public discussion.Besides being more secure than any other type of anti HIV / AIDS predecessors, these drugs can be manufactured in Indonesia, too generic so interested in learning to produce it in their own country.
Again briefly RI Can Make Drugs HIV / AIDS
Indonesia will be able to produce its own generic anti-virus HIV / AIDS as the world of medicine known as the Anti-Retroviral (ARV) drugs that have been imported from India. Indonesia's ability to produce generic drugs made possible following Thailand's willingness to transfer manufacturing technology to Indonesia, said the lecturer at the Faculty of Medicine, University of Indonesia Dr. Syamsuridjal in Canberra, on Tuesday (24 / 9).
September 2008 there was a meeting in Jakarta where the Indonesian government signed a cooperation agreement with Thailand to expand production of ARVs.Manufacture of ARVs in Indonesia Project will be implemented nationally Indo Farma pharmaceutical company, who is an activist said Syamsuridjal Pelita Science Foundation, a foundation that provides moral support and therapy for about 500 people with HIV / AIDS infection in Indonesia.
Therapy of HIV infection / AIDS with antiretroviral drugs is considered effective enough to use it to reduce the risk of dying patients. In addition to mortality rates of HIV / AIDS can be reduced and the number of visits to the hospital they can also be reduced, quality of life of patients with HIV / AIDS can be enhanced so that they can be productive again.
Although highly effective, drug use is still very limited because the price is expensive at around U.S. $ 10,000 worth per year of treatment with the use of long life. Of course it is a challenge because of the nearly 40 million people infected by HIV / AIDS, in fact 90% are in developing countries. But lately the opportunity for developing countries to use drugs is wide open because the drug can be produced in generic form by India, Thailand, China, Vietnam, Cuba and Brazil.
If produced in Indonesia, the price can be reduced up to be U.S. $ 300 (or U.S. $ 25 per month). If this is now Indonesia still bring generic drugs from overseas (India), then later we will be able to produce the drug itself.
This gives great hope for people with HIV / AIDS infection in Indonesia because the drug will not only be obtained in large cities like Jakarta, Surabaya, Medan, but also in other areas. The issue of HIV / AIDS can not be said to finish with the availability of the drug because efforts to tackle HIV / AIDS are also dependent on the existing infrastructure in their respective territories. Means the ability of health workers to use these drugs should also be provided. Because, for most doctors in Indonesia, cases of HIV infection / AIDS is still a new thing.
However, it should not be regarded as an obstacle for the development of the medical world continues to grow, in addition to the WHO is also willing to help for the implementation of this treatment can reach deeper areas with simple laboratory facilities.
In addition to antiretroviral drugs, there are two other types of drugs that are considered equally effective to reduce the risk of dying from this deadly virus.
1. A company called Johnson & Johnson's Tibotec Division who managed to make a drug called Prezista or often called Darunavir also provide a bright spot or hope for the penerita HIV / AIDS acute.
Prezista Drug gives new hope for people who had been taking drugs inhibiting HIV / AIDS virus but have no significant progress. Prezista itself has received approval from the Agency for Food Drugs and America (the U.S. Food and Drug). Research on the drug to prove that 45% of people living with HIV / AIDS who take Prezista for 11 months has decreased the amount of virus in the body they even reached the stage of the HIV virus is undetectable. Compare with other drugs with the same period consumption only managed to reduce the concentration of HIV / AIDS virus is only 10% of the number of people who consume them.
Indeed, the drug has not reached the stage of "cure HIV / AIDS 'at all, but at least this gives the spirit and hope in the future, that someday a drug that actually cure disease can soon be found.
2. One pill a day for HIV Patients
Currently, people living with HIV (AIDS) must take your medicine as much as two to four pills a day. Being less than a decade ago, the drug must be taken to reach 20 to 30 grains per day, which must be taken in exactly the same time and under certain circumstances such as drunk along with food. This is sometimes difficult for many patients to be obedient in living it. The possibility to forget to take the drug also large, thus making the HIV virus into susceptible / resistant to the drug.
Therefore, to facilitate the consumption of drugs for HIV patients, the two drug companies have collaborated to create a drug plan that only needs to be taken once daily. And an estimated mid-2006, it can be marketed.
Two drug companies are Bristol-Myers Squibb Co. and Gilead Sciences Inc.., will combine three HIV drugs they are already widely used today, namely Sustiva drug made by Bristol-Myers Squibb and two other HIV medications, Viread and Emtriva, made by Gilead Sciences.
Both companies will try to combine these three kinds of drugs into a single drug that has the same absorption capacity, the effects of mutual support, can survive long in the body and have the same expiration time as well.
These pills will be reserved for those who have been diagnosed HIV positive, but that has not been taking HIV drugs before.